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6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
01

Overview

This compound is a synthetic small molecule belonging to the pyridazinone class. It is structurally characterized by a dihydropyridazinone core substituted with an iodinated benzyl group and a cyclohexenone moiety. The compound has been studied as an experimental inhibitor of phosphodiesterase 3A and phosphodiesterase 3B (PDE3A/PDE3B), enzymes involved in the regulation of cyclic nucleotide signaling pathways such as cAMP and cGMP. Inhibition of these enzymes can affect processes like cardiac contractility and vascular smooth muscle relaxation. There are no approved therapeutic indications or marketed products containing this molecule; it remains classified as experimental[2][7][10].

Other names
(4R)-3-[4-[[2-(3-Iodophenyl)methyl]-3-oxocyclohexen-1‑yl]amino]phenyl]-4-methyl‑4,5-dihydro‑1H-pyridazin‑6-one(5R)-6-[4‑({2‑[(3-Iodophenyl)methyl]-3‑oxocyclohex‑1-en‑1-y}amino)phenyl]-5-methyl–2,3,4,5-tetrahydropyridazin–3-one
02

Targets

PDE3B (Phosphodiesterase 3B)PDE3A (Phosphodiesterase 3A)

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